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The healthcare sector is undergoing rapid transformation, driven by a deeper understanding of patient needs and the adoption of cutting-edge technologies. At the forefront of this evolution are digital biomarkers and AI/ML, which serve as critical enablers of next-generation healthcare solutions. This paper examines the historical development, impact, and future trajectory of these technologies to explore how they are reshaping the modern healthcare ecosystem. Traditionally, biomarkers have played a crucial role in diagnosing diseases, predicting their progression, and evaluating treatment re

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